O G Opadijo Department of Medicine, University of Ilorin, Ilorin Nigeria
Twenty-eight adult Nigerians (20 males and 8 females) who presented with acute malaria fever were studied for acute cardiac effects of parenteral chloroquine therapy. The parameters studied included the
( 1) Change in heart rate (2) Blood Pressure (3) Electrocardiographic (ECG) intervals including QRS and Q-T intervals. Results showed a significant change in both heart rate and blood pressure compared to baseline readings after the chloroquine injection (P<0.02). There was also a slight but not significant change in QRS duration. There was no appreciable change in rate corrected Q- Tc interval.