ORIGINAL ARTICLE |
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Year : 2003 | Volume
: 6
| Issue : 2 | Page : 53-57 |
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Serum levels of antioxidant vitamins in sicklers and non sicklers in Sokoto metropolis' children
IK Matazu M.Sc 1, LS Bilbis Ph.D 1, NM Jiya FWACP 2, HU Suleiman BSc 1, BS Abdulkareem BSc 1, UA Abubakar BSC 1
1 Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, P.M .B.2346 Sokoto, Nigeria 2 Department of Paediatrics, Usmanu Danfodiyo U niversity Teaching Hospital P.M.B.2370 Sokoto, Nigeria
Correspondence Address:
I K Matazu Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, P.M .B.2346 Sokoto Nigeria
Source of Support: None, Conflict of Interest: None | Check |
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The serum concentrations of vitamins A (retinol ), C ( ascorbic acid ) and E (alpha -tocopherol) of paediatric- age group were determined In sicklers and non-sicklers within the Sokoto metropolis. The levels of the antioxidant vitamins were found to be significantly lower (p < 0.001) In the slckler group when compared to that in non-sicklers. In all cases the concentrations of the antioxidant vitamins were significantly depressed In children with sickle-cell anaemia. The depletion In the levels of the three-antloxldant vitamins may probably account for some of the observed clinical manifestations of sickle-cell anaemia. This shall be the subject of our future lnvestigation(s).
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