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ORIGINAL ARTICLE
Year : 2005  |  Volume : 8  |  Issue : 2  |  Page : 25-29

The effects of highly active antiretroviral therapy on the haematological profile of hiv-infected africans: the Nigerian perspective


Department of Haematology, University of Port Harcourt Teaching Hos pital, P.M.B. 6173, Port Harcourt, Nigeria

Date of Web Publication23-Dec-2014

Correspondence Address:
O A Ejele
Department of Haematology and Blood Transfusion, University of Port Harcourt Teaching Hospital, P.M.B. 6173, Port Harcourt
Nigeria
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Source of Support: None, Conflict of Interest: None


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  Abstract 

Background and Objective: This short -term .....se control study of 70 consecutively recruited HIV-infected and previously antiretroviral nai"ve patients, treated with a combination therapy of stavudine, lamivudine and nevirapine (case) and 30 HIV-infected patients who were yet to start therapy (controls) were studied to evaluate the effect of highly active antiretroviral therapy (HAART) on the haematological parameters of HIV infected individuals.
Methodology: Haematological parameters of haemoglobin, total with cell count, platelet count, erythrocyte sedimentation rate and differentia/leucocyte count were determined at baseline for subjects and control patients. Subjects were placed on HAART (stavudine 40 mg, lamivudine 150mg and nevirapine 200mg) twice daily for twelve weeks.
of haematological parameters was repeated after 12 weeks of HAART in subjects and untreated controls.
Result: The occurrence of anaemia, neutropenia, thrombocytopenia and leucopenia obtained respectively at baseline was 84.3%, 24.3%, 11.4% and 11.4% for subjects but after 12 weeks of HAART these declined respectively to
75.7%, 7.1%, 5.7% and 1.4%. Comparatively, there was an increase from baseline values of 96.7%, 23.3%, 6.7% and
6.7% to 100%, 36.7%, 10% and 36.7% respectively in untreated controls. The difference in mean haematological values of subjects and controls at baseline was not statistically significant (p < O.OS). But after 12 weeks of HAART in subjects and observation in untreated controls, the difference in mean haemaglobin (t = 5.77, p < 0.05), platelet count (I= 2.25, p
< 0.05) and erythrocyte sedimentation rate (t = -3.20 p < 0.05) became statistically significant. While the haemoglobin, platelet and erythrocyte sedimentation rate improved in subjects, it declined in untreated controls.
Conclusion: This study clearly indicates that highly active antiretroviral therapy of two reverse transcriptase
inhibitors (stavudine and lamivudine) and one noll -nucleoside reverse transcriptase inhibitor (nevirapine) may improve
cytopenios in HIV-infected Nigerians and may be used in patients with haematologic intolerance to other regimen.

Keywords: HAART, Heamatological profile, Africans, Nigerians.


How to cite this article:
Ejele O A, Erhabor, Nwauche C A. The effects of highly active antiretroviral therapy on the haematological profile of hiv-infected africans: the Nigerian perspective. Sahel Med J 2005;8:25-9

How to cite this URL:
Ejele O A, Erhabor, Nwauche C A. The effects of highly active antiretroviral therapy on the haematological profile of hiv-infected africans: the Nigerian perspective. Sahel Med J [serial online] 2005 [cited 2024 Mar 28];8:25-9. Available from: https://www.smjonline.org/text.asp?2005/8/2/25/147582

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