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ORIGINAL ARTICLE
Year : 2018  |  Volume : 21  |  Issue : 1  |  Page : 13-17

Immunomodulatory and hepatoprotective properties of Solanum torvum (Turkey berry)


1 Department of Anatomy, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City 300001, Edo State, Nigeria
2 Department of Medical Biochemistry, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City 300001, Edo State, Nigeria

Correspondence Address:
Dr. Kingsley Chukwunonso Agu
Department of Medical Biochemistry, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City 300001, Edo State
Nigeria
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DOI: 10.4103/1118-8561.232777

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Background: Solanum torvum, commonly known as turkey berry, is used majorly as a medicinal plant, especially in Africa. Thus, this research investigated the effects of aqueous leaf extract of S. torvum on the status of liver (alkaline phosphatase [ALP], alanine transaminase, aspartate transaminase, plasma total protein, plasma albumin, plasma globulin, plasma total bilirubin, plasma conjugated bilirubin), hematological profile, as well as on the histology of the liver, spleen, lungs, and bone marrow of treated rats. Methods: Assays were done using ready to use Randox® kits and photomicrographs of various tissues were prepared after histological staining. Results: The results indicated that at the highest dose, there was an activation of the hepatic Kupffer cells and a significant increase in white blood cells (WBCs) and lymphocytes depicting potent immunomodulation in the various tissues. Alanine transaminase and aspartate transaminase increased but decreased at the highest administered dose, while ALP followed an opposite trend. WBCs and platelets level increased significantly. Conclusion: S. torvum aqueous leaf extract possesses potent immunomodulatory and Hepato-protective properties.


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