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 Table of Contents  
ORIGINAL ARTICLE
Year : 2019  |  Volume : 22  |  Issue : 1  |  Page : 13-17

Ocular comorbidities in children with strabismus in Benin City


1 Department of Ophthalmology, Paediatric and Adult Strabismus Unit, University of Benin Teaching Hospital, Benin City, Nigeria
2 Department of Ophthalmology, Paediatric and Adult Strabismus Unit, Irrua Specialist Hospital, Irrua, Edo, Nigeria

Date of Submission30-May-2017
Date of Acceptance14-Jan-2018
Date of Web Publication28-Mar-2019

Correspondence Address:
Dr. Valentina Winifred Okeigbemen
Department of Ophthalmology, Paediatric and Adult Strabismus Unit, University of Benin Teaching Hospital, Benin City, Edo
Nigeria
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DOI: 10.4103/smj.smj_41_17

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  Abstract 


Background: Strabismus is the misalignment of the visual axis. Certain comorbidities have been found to be associated with strabismus. These must be identified and treated. Objective: The aim of this study was to determine the ocular comorbidities associated with strabismus in children 15 years and below presenting to the eye clinic of University of Benin Teaching Hospital, Benin City, from January 2014 to December 2014. Patients and Methods: This is a prospective hospital-based observational study of consecutive patients seen in the eye clinic. Results: Fifty-five children presented with strabismus accounting for 2.6% of the total number of 2112 new cases. There were 30 males (54.5%) and 25 females (45.5%) giving a male-to-female ratio of 1:0.83. The age range was from 5 months to 14 years. The mean age was 4.7 years with a standard deviation of ± 3.4 years. Thirty-seven (67.3%) of the patients were under 5 years of age. Forty-seven (85.5%) patients had esotropia, six (10.9%) had exotropia, and two (3.6%) had hypertropia. Vision-impairing comorbidities included refractive error in 33 (64.7%) patients, cataract in 9 (17.6%) patients, corneal opacity in 1 (2.0%) patient, and retinopathy of prematurity in 1 (2.0%) patient. Nonvision-impairing disorders were microcornea, conjunctivitis, and nasolacrimal duct obstruction. The relationship between ocular comorbidity and types of strabismus was not statistically significant (P > 0.05). Conclusion: Detailed assessment to identify the comorbidities associated with strabismus is recommended. This could improve the management of this condition.

Keywords: Children, comorbidities, refractive error, strabismus


How to cite this article:
Okeigbemen VW, Momoh N. Ocular comorbidities in children with strabismus in Benin City. Sahel Med J 2019;22:13-7

How to cite this URL:
Okeigbemen VW, Momoh N. Ocular comorbidities in children with strabismus in Benin City. Sahel Med J [serial online] 2019 [cited 2019 Aug 23];22:13-7. Available from: http://www.smjonline.org/text.asp?2019/22/1/13/255168




  Introduction Top


Strabismus is the misalignment of the visual axis.[1] The global prevalence of strabismus in the general population has been found to be 3%–5%.[2] The prevalence of strabismus in the African population is quite low compared to Caucasians or Asian studies. Ayanru reported that strabismus was not common as it was seen in only 1.9/1000 patients in Benin.[3] Abiose et al. found strabismus in only 0.7% of secondary schoolchildren in Kaduna, Nigeria.[4] The study in Ilesa local government area reported a prevalence of 0.3% among primary and secondary schoolchildren.[5] In Anambra state, southeastern Nigeria, among children in three rural communities, a prevalence of 0.4% was observed.[6] Similar prevalence was found in the studies done in Ibadan and Ilorin.[7],[8] A study on prevalence and pattern of strabismus in primary schools in Benin City, Nigeria, revealed a prevalence of 0.89%.[9] However, higher prevalence rates have been found in more recent Nigerian studies ranging from 2.2% to 8.8%.[10],[11],[12]

The Multi-Ethnic Pediatric Eye Disease Study, a population-based study conducted among children aged 6–72 months in Los Angeles County, California, reported that strabismus was detected in 2.4% of Hispanic/Latino children and 2.5% of African-American children (P = 0.81) and was more prevalent in older children than in younger ones.[13]

Studies from the United Kingdom also conform to the generally accepted prevalence of about 3%–5%. The Avon longitudinal study of Parents and Children study, conducted in Bristol, reported that 2.3% (95% confidence interval 2.0%–2.7%) had manifest strabismus.[14] In Brazil, of the 1015 elementary and high school students examined, 2.9% had strabismus.[15]

Various studies have shown strabismus to be associated with other comorbidities such as refractive error (hypermetropia and myopia), nystagmus, cataract, corneal opacity, ocular coloboma, and amblyopia.[16],[17],[18],[19],[20] High ametropia (hypermetropia more than myopia) and anisometropia have been known to favor the development of strabismus.[16]

The treatment of strabismus typically consists of spectacle correction followed sometimes with orthoptic exercises directed toward improving muscle strength. These exercises have advanced beyond just muscle strengthening to include training and rehabilitation of the eye–brain connection (neuroplasticity) involved in vision in order to maintain ocular alignment. Thereafter, surgery can be done for those with a significant nonaccommodative element.[21]

Detailed ocular assessment is important in patients with strabismus to enable one identify other ocular conditions that could adversely affect the management outcome. The aim of this study was to evaluate the relationship between strabismus and associated ocular comorbidities such as visual pathway opacity (cataract and corneal opacity), retinopathy of prematurity, and uncorrected high refractive errors such as hypermetropia, myopia, and astigmatism.


  Patients and Methods Top


This was a prospective hospital-based observational study of consecutive patients 15 years and below presenting to the eye clinic of the University of Benin Teaching Hospital, Benin City. Ethical approval (ADM/E 22/A/VOL. VII/ 1161) was obtained on March 2nd, 2015 from Ethics and Research Committee, University of Benin Teaching Hospital. All the procedures have been carried out as per the guidelines given in Declaration of Helsinski 2013. Furthermore, consent to enlist a child was obtained from the parents or caregiver and confidentiality of information was ensured. All children presenting with strabismus from January 2014 to December 2014 were included in the study. A structured questionnaire was used to collect the data. The information obtained included the child's age, gender, religion, level of education, history of deviation of the eyes, and general pediatric history.

Visual acuity was measured at 6 meters with the Tumbling E chart and Snellen chart for the older children, fixation and/or following of light source, resistance to occlusion, recognition of picture charts, and objects for the much younger children. Assessment of the angle of deviation using the corneal light reflex (Hirschberg test) for near and distance as well as the single prism test was done.

Examination of the anterior segment was done using the pen torch and the Carl Zeiss portable slit lamp, and the posterior segment using a Welch Allyn direct ophthalmoscope. Dilated fundus examination with binocular indirect ophthalmoscope and refraction under sedation for the uncooperative child was carried out. Cycloplegic refraction using guttae atropine twice a day for 3 days before the test day was performed.

Data collated were analyzed using the Statistical Package for the Social Sciences 21 (IBM Corp., Armonk, NY, USA). Frequency distribution tables were generated. The ranges and means were determined. The relationship between categorical data was analyzed using Chi-square and Fisher's exact tests. At the adopted confidence level of 95%, a P value of 0.05 (5%) or less was regarded as significant.


  Results Top


A total of 2112 new patients comprising of both adults and children were seen in the eye clinic in the period under review. Fifty-five children presented with strabismus accounting for 2.6% of the total number of new cases. Thirty (n = 30) patients were males (54.5%) and 25 females (45.5%) giving a male-to-female ratio of 1:0.83. The age range was from 5 months to 14 years [Table 1]. The mean age was 4.7 years with a standard deviation of ± 3.4 years. Thirty-seven (67.3%) of the patients were under 5 years of age, with majority being 1 year and below. Strabismus was more common in children between 0 and 5 years of age. Esotropia was the most common type in this age group but was not found to be statistically significant (P = 0.78). Forty percent (n = 22) of them were preschoolers, 27.3% (n = 12) were in nursery school, 29.1% (n = 16) were in primary school, and 3.6% (n = 2) were secondary school students.
Table 1: Age distribution of children and type of strabismus

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About 51 (92.7%) of this study sample had other associated ocular comorbidities [Table 2]. Vision-impairing comorbidities included corneal opacity in 1 (2.0%) patient, cataract in 9 (17.6%) patients, about 4 of the patients with cataract also had microcornea, retinopathy of prematurity in 1 (2.0%) patient, and refractive error in 33 (64.7%) patients. Nonvision-impairing disorders were microcornea in 4 (7.8%), conjunctivitis in 2 (3.9%), and nasolacrimal duct obstruction in 1 (2.0%) patient. The relationship between ocular comorbidity and types of strabismus was not statistically significant (P > 0.05).
Table 2: Ocular comorbidity versus strabismus

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Thirty-three out of the 55 (60%) patients had refractive error [Table 3]. It is important to note that more than half of the patients (28 out of the 33 patients) had hypermetropia (84.8%). All the patients who had hypermetropia also had esotropia.
Table 3: Association of refractive error with type of strabismus

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  Discussion Top


Previous studies on strabismus have reported varying prevalence rates.[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16] In this study, the prevalence of strabismus was found to be 2.6%. This is slightly below the global prevalence of 3%–5% but agrees with prevalence rates reported in recent studies.[10],[11],[12],[13],[14],[15],[16] It is believed that in recent times, the awareness that strabismus is treatable has improved the health-seeking behavior of parents. This has led to an increasing number presenting with their children at an earlier age than was seen in previous studies.[13],[14] There was a fairly equal distribution of males and females which agrees with a previous study conducted in Benin City.[9] Majority of the patients (63.7%) in this study were under the age of 5 years with the age range from 5 months to 14 age at presentation.

Strabismus has been found to be associated with refractive error. Studies have shown esotropia to be commonly associated with hypermetropia and exotropia to be associated with myopia.[7],[8],[9],[16] This was observed in this study. One of the children who had high hypermetropia (+5.00 DS) and esotropia (60 prism diopters) had treatment for retinopathy of prematurity. Kushner[22] reported a higher incidence of strabismus, amblyopia, and high refractive error among children with retinopathy of prematurity. This shows that strabismus can coexist with other ocular disorders.

The high incidence of refractive error in this study (64.7%) agrees with the study by Baiyeroju and Owoeye[7] as well as Zhu et al.[23] where 50% and 41.6% of the children had strabismus with refractive error, respectively. The study by Zhu et al. highlighted the close association between childhood strabismus and refractive error, recommending that strabismus should be considered when managing childhood refractive error.

Strabismus can coexist with cataract. Nine out of 55 patients (16.3%) had cataract in this study. This high incidence agrees with Umar et al.[24] in Kaduna who reported strabismus to occur in 35.4% of children with cataract. Strabismus could occur following cataract due to poor vision induced by the cataract and inability to maintain adequate sensory and motor fusion mechanisms.[25] This is more observed when the patient has unilateral cataract. The study by Spanou et al.[26] has shown the incidence of strabismus to be higher in patients with unilateral cataract (27.4%) compared to those with bilateral cataract (19.6%). All the patients in this study had unilateral cataract.

Ocular comorbidities identified in this study included vision-impairing diseases such as corneal opacity, cataract, retinopathy of prematurity, and refractive error. Nonvision-impairing disorders were microcornea, conjunctivitis, and nasolacrimal duct obstruction. These diseases have been reported in previous studies to be associated with strabismus.[16],[17],[18],[19],[20] Gu et al.[20] reported amblyopia and strabismus which developed secondary to monocular corneal opacity following suspected epidemic keratoconjunctivitis. In this study, one patient had monocular corneal opacity which cause could not be determined.

This shows the need to fully investigate a patient with strabismus and identify coexisting pathologies, which when diagnosed would need to be managed appropriately in order to improve management outcome in strabismus. For patients who have refractive error, they should be corrected with spectacles and the angle of deviation monitored. Once the angle is stable which means there is no further reduction in the angle, surgical correction can be effected for the nonaccommodative part. Patients with cataract would need to have cataract extraction as part of their management. In a study which combined both cataract and strabismus surgeries, the researchers concluded that in selected cases, combined surgery optimized the alignment of the visual axes, improved visual acuity, and minimized the need for additional procedures.[27] Our findings being hospital-based may not be a true representative of what is obtainable in the general population.


  Conclusion Top


The need to fully investigate the patient with strabismus cannot be overemphasized. This study has shown that strabismus can coexist with other ocular disorders which could be vision impairing, thereby interfering with visual prognosis. Some of these conditions are treatable once identified. It is, therefore, important to make the diagnosis and institute appropriate treatment of these ocular conditions.

Acknowledgment

We wish to thank the residents of the Department of Ophthalmology who assisted us during this study.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

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Ajaiyeoba AI, Isawumi MA, Adeoye AO, Oluleye TS. Prevalence and causes of eye disease amongst students in South Western Nigeria. Ann Afr Med 2006;5:197-203.  Back to cited text no. 5
    
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Baiyeroju-Agbeja AM, Owoeye JF. Strabismus in children in Ibadan. Niger J Ophthalmol 1998;6:31-3.  Back to cited text no. 7
    
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Azonobi IR, Olatunji FO, Adido J, Osayande OO. Vision of strabismic children in Ilorin, Nigeria. Niger J Ophthalmol 2008;6:12-5.  Back to cited text no. 8
    
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Williams C, Northstone K, Howard M, Harvey I, Harrad RA, Sparrow JM, et al. Prevalence and risk factors for common vision problems in children: Data from the ALSPAC study. Br J Ophthalmol 2008;92:959-64.  Back to cited text no. 14
    
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Amorin GC, Carlos A, Araken B, Fernando O. Prevalence of strabismus among students in Nata-Brazil. Arq Bras Oftalmol 2004;67:791-4.  Back to cited text no. 15
    
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Ribero CM, Estrabismo S. Classificacao e etiopatogenia. In: Souza-Dias CR, editor. Almedia Estrabismo. Sao Paulo: Roca; 1998. p. 71-3.  Back to cited text no. 16
    
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Jacobson L, Ygge J, Flodmark O, Ek U. Visual and perceptual characteristics, ocular motility and strabismus in children with periventricular leukomalacia. Strabismus 2002;10:179-83.  Back to cited text no. 17
    
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Nakamura KM, Diehl NN, Mohney BG. Incidence, ocular findings, and systemic associations of ocular coloboma: A population-based study. Arch Ophthalmol 2011;129:69-74.  Back to cited text no. 19
    
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Gu B, Son J, Kim M. Amblyopia and strabismus by monocular corneal opacity following suspected epidemic keratoconjunctivitis in infancy. Korean J Ophthalmol 2011;25:257-61.  Back to cited text no. 20
    
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24.
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[PUBMED]  [Full text]  
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26.
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  [Table 1], [Table 2], [Table 3]



 

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