Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Home Print this page Email this page
Users Online:: 236
ORIGINAL ARTICLE
Year : 2004  |  Volume : 7  |  Issue : 3  |  Page : 80-83

Relxant effect of enantia clorantha on the gastrointestinal smooth muscle of rodents


Department of Pharmacology, College of Medicine, Univers ity of Lagos , Nigeria

Correspondence Address:
E O Agbaje
Department of Pharmacology, College of Medicine, Univers ity of Lagos ,
Nigeria
Login to access the Email id


Rights and Permissions

T he effects of aqueous boiled and evaporated extract of Enantia chlorantha ( 0 .8 and 1 .5g kg' 1) were studied on certain functions of the gastrointestinal tract (G IT ) vis-a-vis, gastrointestinal fluid accumulation an d motility a s well as castor oil induced diarrhoea, using adult rat s and mice that have been starved 14-20h prior to experiment. The extract was found to exert inhibitory action on the G IT , w hich result ed in red uced percentage tran sit in the herbal-drug-treated animals , when compared with cont rols ( p < 0.05 ). While atropine (0 .25mgkg·1 produced a great er reduction in t he rat e of intestinal transit , 0.1 mgkg· 1 carbachol nced intestinal motility. Furthermore, E . chlorantha extract reduced the intensity of castor oil induced diarrhoea (p < 0 .05 ) . A similar trend of E . chlorantha' s effeect was observed in GIT fluid a ccumulated in the animals (p > 0 .05 ) . astly, graded doses ( 12 .3- 1 96 .8 mg) of the herbal preparation t hat were se pa ra t el y tested on t he rat duodenum and il eum also produced relaxation of the isolat ed tissues similar t o 0.55xl o·4 M adren aline. although not as efficacious . Propranolol , ( 0 .34xl0·5 M); a {3-receptor blocker , \.ant ag onized t he effect s of adrenaline and E . chlorantha in-vitro.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed456    
    Printed14    
    Emailed0    
    PDF Downloaded47    
    Comments [Add]    

Recommend this journal