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Year : 2004  |  Volume : 7  |  Issue : 3  |  Page : 80-83

Relxant effect of enantia clorantha on the gastrointestinal smooth muscle of rodents

Department of Pharmacology, College of Medicine, Univers ity of Lagos , Nigeria

Correspondence Address:
E O Agbaje
Department of Pharmacology, College of Medicine, Univers ity of Lagos ,
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T he effects of aqueous boiled and evaporated extract of Enantia chlorantha ( 0 .8 and 1 .5g kg' 1) were studied on certain functions of the gastrointestinal tract (G IT ) vis-a-vis, gastrointestinal fluid accumulation an d motility a s well as castor oil induced diarrhoea, using adult rat s and mice that have been starved 14-20h prior to experiment. The extract was found to exert inhibitory action on the G IT , w hich result ed in red uced percentage tran sit in the herbal-drug-treated animals , when compared with cont rols ( p < 0.05 ). While atropine (0 .25mgkg·1 produced a great er reduction in t he rat e of intestinal transit , 0.1 mgkg· 1 carbachol nced intestinal motility. Furthermore, E . chlorantha extract reduced the intensity of castor oil induced diarrhoea (p < 0 .05 ) . A similar trend of E . chlorantha' s effeect was observed in GIT fluid a ccumulated in the animals (p > 0 .05 ) . astly, graded doses ( 12 .3- 1 96 .8 mg) of the herbal preparation t hat were se pa ra t el y tested on t he rat duodenum and il eum also produced relaxation of the isolat ed tissues similar t o 0.55xl o·4 M adren aline. although not as efficacious . Propranolol , ( 0 .34xl0·5 M); a {3-receptor blocker , \.ant ag onized t he effect s of adrenaline and E . chlorantha in-vitro.

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