Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Home Print this page Email this page
Users Online:: 366
Year : 2019  |  Volume : 22  |  Issue : 4  |  Page : 164-170

Circulating brain-derived neurotrophic factor level in patients with primary open angle glaucoma

1 Medical Services Branch, Headquarters, Nigerian Air Force, Abuja, Nigeria
2 Department of Ophthalmology, Faculty of Clinical Sciences, College of Health Sciences, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria
3 Nigeria Navy Medical Services, Naval Medical Centre, Victoria Island, Lagos, Nigeria
4 Department of Physiology, Neuroscience and Pathophysiology Unit, Faculty of Basic Medical Sciences, College of Health Sciences, Bayero University, Kano, Nigeria

Correspondence Address:
Dr. Isyaku Umar Yarube
Department of Physiology, Neuroscience and Pathophysiology Unit, Bayero University, Kano
Login to access the Email id

DOI: 10.4103/smj.smj_63_18

Rights and Permissions

Background: Glaucoma constitutes a serious health problem in Nigeria and beyond. It is a leading cause of bilateral blindness and its burden remains high. There is a paucity of literature on the levels of circulating brain-derived neurotrophic factor (BDNF) in health and disease among Africans. In addition, the dynamics and reasons for variation in the levels of BDNF in the local population of glaucoma patients are yet to be demonstrated. Objective: This study determined the circulating level of BDNF and factors associated with it among glaucoma patients. Materials and Methods: Serum concentration of BDNF and other oculo-visual and sociodemographic characteristics were determined in glaucoma patients and controls. Data were processed using IBM SPSS Statistics version 20. Results: Forty-four adult glaucoma patients of both sexes and 41 nonglaucoma controls matched for age and sex with an average age of about 50 years were studied. BDNF level among the glaucoma patients was higher (2.578 ± 1.394) than that of the controls (1.745 ± 0.707) (t = 3.436, P = 0.001). Glaucoma patients who were blind had the lowest levels of circulating BDNF (P = 0.022); the level of BDNF in the naïve patients (not yet placed on medication) is about five times less than in those patients placed on medication (P = 0.001). Circulating BDNF was associated with glaucoma treatment among the patients. Conclusion: The level of circulating BDNF in primary open angle glaucoma patients on treatment is high than those who were not on treatment. It influenced by coexisting medical conditions.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded148    
    Comments [Add]    

Recommend this journal