ORIGINAL ARTICLE
Year : 2004 | Volume
: 7 | Issue : 3 | Page : 80--83
Relxant effect of enantia clorantha on the gastrointestinal smooth muscle of rodents
EO Agbaje, OO Okubadejo Department of Pharmacology, College of Medicine, Univers ity of Lagos , Nigeria
Correspondence Address:
E O Agbaje Department of Pharmacology, College of Medicine, Univers ity of Lagos , Nigeria
T he effects of aqueous boiled and evaporated extract of Enantia chlorantha ( 0 .8 and 1 .5g kg�SQ� 1) were studied on certain functions of the gastrointestinal tract (G IT ) vis-a-vis, gastrointestinal fluid accumulation an d motility a s well as castor oil induced diarrhoea, using adult rat s and mice that have been starved 14-20h prior to experiment.
The extract was found to exert inhibitory action on the G IT , w hich result ed in red uced percentage tran sit in the herbal-drug-treated animals , when compared with cont rols ( p < 0.05 ). While atropine
(0 .25mgkg·1
produced a great er reduction in t he rat e of intestinal transit , 0.1 mgkg· 1 carbachol
nced intestinal motility. Furthermore, E . chlorantha extract reduced the intensity of castor oil induced diarrhoea (p < 0 .05 ) . A similar trend of E . chlorantha�SQ� s effeect was observed in GIT fluid a ccumulated in the animals (p > 0 .05 ) .
astly, graded doses ( 12 .3- 1 96 .8 mg) of the herbal preparation t hat were se pa ra t el y tested on t he rat duodenum and il eum also produced relaxation of the isolat ed tissues similar t o 0.55xl o·4 M adren aline. although not as efficacious . Propranolol , ( 0 .34xl0·5 M); a {3-receptor blocker ,
\.ant ag onized t he effect s of adrenaline and E . chlorantha in-vitro.
How to cite this article:
Agbaje E O, Okubadejo O O. Relxant effect of enantia clorantha on the gastrointestinal smooth muscle of rodents.Sahel Med J 2004;7:80-83
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How to cite this URL:
Agbaje E O, Okubadejo O O. Relxant effect of enantia clorantha on the gastrointestinal smooth muscle of rodents. Sahel Med J [serial online] 2004 [cited 2024 Mar 29 ];7:80-83
Available from: https://www.smjonline.org/article.asp?issn=1118-8561;year=2004;volume=7;issue=3;spage=80;epage=83;aulast=Agbaje;type=0 |
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