Sahel Medical Journal

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 23  |  Issue : 3  |  Page : 147--152

Relationship between microalbuminuria and glomerular filtration rate in children with sickle cell anemia in steady state


Rasaki Aliu1, Jalo Iliya1, Patience Ngozi Obiagwu2, Adamu Sani3 
1 Department of Paediatrics, Federal Teaching Hospital, Gombe State University, Gombe State, Nigeria
2 Department of Paediatrics, Aminu Kano Teaching Hospital, Bayero University, Kano State, Nigeria
3 Department of Chemical Pathology, Federal Teaching Hospital, Gombe State University, Gombe State, Nigeria

Correspondence Address:
Dr. Rasaki Aliu
Department of Pediatrics, Federal Teaching Hospital, Gombe State University, Gombe
Nigeria

Background: Microalbuminuria (MA), a common phenomenon in children with sickle cell anemia (SCA), is defined as an increased urinary albumin–creatinine ratio of 30–300 mg/g of creatinine in an early morning or random urine specimen. Whereas some studies have shown that MA reflects early kidney damage, other studies have documented that it is a manifestation of advanced nephropathy. The reports about the relationship between glomerular filtration rate (GFR) and MA in children with SCA are conflicting. Materials and Methods: This was a longitudinal study. Serum creatinine, GFR, and albumin–creatinine ratio were determined at baseline. The individuals were followed up over 3 months during which albumin–creatinine ratio and GFR were assayed monthly, and the relationship between them was determined. Results: One hundred and seventy children aged 1–18 years with SCA and MA were studied. The mean albumin–creatinine ratio was 120.9 ± 66.8 mg/g, 138.32 ± 101.79 mg/g, 117.12 ± 78.09 mg/g, and 106.73 ± 38.82 mg/g at baseline, 1, 2, and 3 months, respectively, whereas the mean GFR was 121.7 ± 33.0 ml/min/1.73 m2, 117.69 ± 29.70 ml/min/1.73 m2, 117.56 ± 35.77 ml/min/1.732 m2, and 116.22 ± 30.28 ml/min/1.73 m2 at baseline, 1, 2, and 3 months, respectively. There was no significant relationship between MA and GFR in the participants throughout the study period (Pearson's correlation coefficients: 0.050, 0.250, 0.268, and 0.143 and corresponding P: 0.95, 0.88, 0.15, and 0.36). Conclusions: GFR is normal in SCA children with MA. There is no significant relationship between MA and GFR in children with SCA.


How to cite this article:
Aliu R, Iliya J, Obiagwu PN, Sani A. Relationship between microalbuminuria and glomerular filtration rate in children with sickle cell anemia in steady state.Sahel Med J 2020;23:147-152


How to cite this URL:
Aliu R, Iliya J, Obiagwu PN, Sani A. Relationship between microalbuminuria and glomerular filtration rate in children with sickle cell anemia in steady state. Sahel Med J [serial online] 2020 [cited 2020 Nov 29 ];23:147-152
Available from: https://www.smjonline.org/article.asp?issn=1118-8561;year=2020;volume=23;issue=3;spage=147;epage=152;aulast=Aliu;type=0